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  • 7:39 AM, Saturday, 31 Oct 2020

Department of Chemistry
     
Sreejalekshmi K.G.
Associate Professor
 
Office
Tel:+91-471-2568539
Fax:
Email:sreeja@iist.ac.in













Education
  • Ph.D. (2006, Univ. of Kerala)
  • M.Sc. (1999, Univ. of Kerala)

Course Offered
  • Environmental Science and Engineering (B.Tech.)
  • Introduction to smart and intelligent materials (B.Tech.)
  • Material Characterisation Techniques (M. Tech.)
  • Smart and Intelligent Materials (M.Tech.)
  • Computational Chemistry (M.Tech.)
  • Basic course on Astrobiology (B.Tech.)

Experience
  • September 2016 - onwards              Associate Professor, Department of Chemistry, Indian Institute of Space Science and Technology, Thiruvananthapuram

  • May 2010 - August 2016                  Assistant Professor, Department of Chemistry, Indian Institute of Space Science and Technology, Thiruvananthapuram

  • September 2007 – April 2010            Reader, Department of Chemistry, Indian Institute of Space Science and Technology, Thiruvananthapuram

  • December 2006 – September 2007    Postdoctoral researcher (RA, CSIR)

                     LPA, BMT, SCTIMST, Thiruvananthapuram, India

     

                     Design of novel polymeric materials as tissue engineering scaffolds

  • July 1999 – February 2006                 Doctoral Research

                    Department of Chemistry, University of Kerala, Thiruvananthapuram India

     

                    Combinatorial synthesis of medicinally relevant heterocycles, their precursors and structure evaluation by spectral methods


Research Work / Area
  • Synthetic Organic Chemistry
  • Combinatorial Chemistry for material development
  • Materials for molecular therapeutics
  • Dendrimer synthesis and applications 
  • Drug discovery and Space Medicine
  • Space Life sciences 
  • Supramolecular assemblies

Funded Project

N-containing heterocycles as aurora kinase inhibitors - computational design and library synthesis (IIST funded, completed)

Spaceflight induced changes in kidney stone formation in Drosophila Melanogaster  (Biology payload for Gaganyaan, HSFC-ISRO funded)


Awards
  • Awarded Research Associateship (RA) by Council of Scientific & Industrial Research, India.
  • II Rank holder in M.Sc. Chemistry, University of Kerala, July 1999.
  • Awarded Junior Research Fellowship (JRF) by Council of Scientific & Industrial Research- University Grants Commission (CSIR- UGC), India.
  • Acquired eligibility for Lectureship in Chemical Sciences by qualifying National eligibility test (NET) conducted by CSIR- UGC held in December 2002.
  • Awarded Junior Research Fellowship (JRF) by University of Kerala, India.
Publications:
  • R Radhakrishnan, KG Sreejalekshmi. Computational Design, Synthesis and Structure Property Evaluation of 1, 3-Thiazole Based Colour Tunable Multiheterocyclic Small Organic Fluorophores as Multifunctional Molecular Materials. - The Journal of Organic Chemistry, DOI: 10.1021/acs.joc.7b02978 (2018)
  • S Titus, KG Sreejalekshmi. Enriching biologically relevant chemical space around 2-aminothiazole template for anticancer drug development. Medicinal Chemistry Research, 27 (1), 23-36 (2017)
  • K. A. Krishnan, K.G. Sreejalekshmi, Vinu V. Dev, Sibin Antony, H. Mahadevan. Removal of Cu(II) from aqueous phase using tailor made sulphur impregnated activated carbon inspired by Claus Process. Desalination and Water Treatment, 80, 214–222, (2017)
  • R. Radhakrishnan, K.G. Sreejalekshmi. Fluorophores based on a minimal thienylthiazole core: towards multifunctional materials with solid state red emissions, solvatochromism and AIE behavior. RSC Advances, 2016, 6 (39), 32705-32709
  • R. Radhakrishnan, K.G. Sreejalekshmi. Expanding Donor-Acceptor toolbox with a minimal 5-(thiophen-2-yl)-1,3-thiazole core: Transition metal-free synthesis and molecular design for HOMO-LUMO energy modulations. New J Chemistry, 2016, 40 (4), 3036-3039.
  • K.A. Krishnan, K.G. Sreejalekshmi, V. Vimexen, V.V. Dev. Evaluation of adsorption properties of sulphurised activated carbon for the effective and economically viable removal of Zn (II) from aqueous solutions.Ecotoxicology and environmental safety, 2016, 124, 418-425. 
  • S. Titus and K.G.Sreejalekshmi. Propeller-shaped molecules with thiazole hub: structural landscape and hydrazone cap mediated tunable host behavior in 4-hydrazino-1,3-thiazoles. CrysEngComm, 2015, 17 (31), 5978-5986.
  • K.A. Krishnan, S. Sini Suresh, S. Arya, K.G. Sreejalekshmi.  Adsorptive removal of 2,4-dinitrophenol using active carbon: kinetic and equilibrium modeling at solid-liquid interface. Desalination and Water Treatment, 2015, 54 (7), 1850-1861.
  • S. Titus and K.G.Sreejalekshmi. One-pot four-component synthesis of 4-hydrazinothiazoles: novel scaffolds for drug discovery. Tetrahedron Letters, 2014, 55 (40), 5465-5467.
  • K.G. Sreejalekshmi and K.N. Rajasekharan. One-pot sequential multicomponent route to 2,4-diaminothiazoles- facile approach to bioactive agents for cancer therapeutics. Tetrahedron Letters, 2012, 53(28), 3627-3629.
  • K.A. Krishnan, K.G. Sreejalekshmi, R.S. Baiju. Nickel(II) adsorption onto biomass based activated carbon obtained from sugarcane bagasse pith. Bioresource Technology, 2011, 102 (22), pp. 10239-10247.
  • K.G. Sreejalekshmi and P.D. Nair. Biomimeticity in tissue engineering scaffolds through synthetic peptide modifications – altering chemistry for enhanced biological response. Journal of Biomedical Materials Research – Part A, 2011, 96 (2), pp. 477-491.
  • K.G. Sreejalekshmi, A Facile, Sequential Multicomponent Approach to N-Amino amidinothioureas – Versatile Synthons to Bioactive Heterocycles. Phosphorus, Sulfur, and Silicon and the Related Elements, Phosphorus, Sulfur and Silicon and the Related Elements, 2010, 185 (9), pp. 1830-1837.
  • K.A. Krishnan, K.G. Sreejalekshmi, S. Varghese. Adsorptive retention of citric acid onto activated carbon prepared from Havea braziliansis sawdust: Kinetic and isotherm overview. Desalination, 2010, 257 (1-3), pp. 46-52.
  • K. Anoop Krishnan, K.G. Sreejalekshmi, S. Varghese, T.S. Anirudhan. Removal of EDTA from aqueous solutions using activated carbon prepared from sawdust of rubber wood: Kinetic and equilibrium modeling. CLEAN – Soil, Air, Water, 2010, 38 (4), pp. 361-69.
  • K.G. Sreejalekshmi, K. Anoop Krishnan, T.S. Anirudhan, Adsorption of Pb(II) and Pb(II)-Citric acid on sawdust activated carbon: Kinetic and equilibrium isotherm studies. Journal of Hazardous Materials, 2009, 161 (2-3), pp. 1506-1513.
  • T.F.A.F. Reji, S.K.C. Devi, K.K. Thomas, K.G. Sreejalekshmi, S.L. Manju, M..Francis, S.K.  Philip, A. Bharathan,  K.N.  Rajasekharan. Synthesis and cytotoxicity studies of thiazole analogs of the anticancer marine alkaloid dendrodoine. Indian Journal of Chemistry Section B,  2008, 47 (7), pp. 1145-1150.
  • K.G. Sreejalekshmi, S.K.C. Devi, K.N.Rajasekharan. An efficient protocol for solid phase aminothiazole synthesis. Tetrahedron Letters, 2006, 47 (35), pp. 6179-6182.
  • S. Sengupta,  S.L Smitha, N.E. Thomas, T.R. Santhoshkumar, S.K.C. Devi, K.G. Sreejalekshmi, K.N. Rajasekharan. British Journal of Pharmacology, 2005, 145 (8), pp. 1076-1083.

Patents

  • K.G. Sreejalekshmi and S. Titus. Indian Patent (Filed) 2462/CHE/2013; 18.06.2013; Substituted 4-hydrazinothiazoles and processes for their preparation. 
Articles in Books
  • K.G. Sreejalekshmi and K.A. Krishnan. Chemical Aspects of Polyphenols-a short survey from molecular structure to reactivity in the book “Chemistry and Biotechnology of Polyphenols: Fundamentals and Applications” Eds. Sabu A., Roussos S., Aguilar C.N. CIBET Publishers, Thiruvananthapuram, 2011.
Seminars / Conferences Attended
  • C Mrudul, Sam Noble and K G Sreejalekshmi. "Design of Flapping Wing Mechanism for Bionic Micro Aerial Vehicle", Fourth International Conference on Materials Mechanics and Management from 13th -15th July 2017, CET, Trivandrum, Kerala
  • Dona Mariya Vincent, Rakesh R., Sarah Titus, K. G. Sreejalekshmi. “Colorimetric sensors based on Novel 2-amino- 4-hydrazinothiazoles for anion detection”. National Conference on Recent Trends in Material Science & Technology (NCMST- 2016), July 12-14, 2016, Indian Institute of Space Science and Technology, Thiruvananthapuram, Kerala, India
  • E. Swathi, K.G. Sreejalekshmi. “Effect of microphase separation on shape memory properties of polyurethane”, National Conference on Recent Trends in Materials Science & Technology (NCMST-2016), July 12-14, 2016, Indian Institute of Space Science and Technology, Thiruvananthapuram, Kerala, India.
  • Rakesh R., K.G. Sreejalekshmi. “Exploring 1,3-thiazole scaffolds for structure property relationships and dendritic architecture”. 18th Tetrahedron Symposium, June 27-30, 2017, Budapest, Hungary. (accepted for presentation)
  • Noufal M.C., Sarah Titus, Dona Maria Vincent, Rakesh R., K.G. Sreejalekshmi. “Azaindole fragment decoration on 4-hydrazinothiazole scaffold as a useful strategy for designing aurora kinase inhibitors: Insights from virtual screening of a synthetically feasible combinatorial library” International Conference on Drug Design, April 7-9, 2017, JNU-New Delhi, India.(BEST POSTER AWARD)
  • Rakesh R., K. G. Sreejalekshmi. “Thienylthiazole: a promising core for theranostics” National Seminar on Current Trends in Chemistry (CTriC 2017), February 3-4, 2017, Cochin University of Science and Technology, Kochi, Kerala, India.
  • E. Swathi, R. Rakesh, S.Titus, K.G. Sreejalekshmi. “A combined theoretical and experimental investigation on the effect of microphase separation on shape memory behaviour of polyurethane” Macro-2017- International Conference on Polymer Science and Technology, January 8-11, 2017, Thiruvananthapuram, Kerala, India 2017.
  • Rakesh R., K. G. Sreejalekshmi. “Diversity-oriented design and synthesis of multi-heterocyclic donor acceptor hybrid cores based on 1, 3-thiazole”. 21st International Conference on Organic Synthesis (ICOS 21), December 11-16, 2016, IIT Mumbai, India
  •  S     S.Titus and K.G. Sreejalekshmi, Coumarinoyl-1,3-thiazole conjugated PAMAM dendrimers as highly emissive  solvatochromic fluorescent nanoprobes. Polymer Conference for Young Researchers (PCYR-2015), 18th December 2015, NIIST, Thiruvananthapuram.
  • R. Rakesh and K.G. Sreejalekshmi, Exceptional large Stokes shift fluorophores: Design, synthesis and rationalization of photophysical properties of novel heterocyclic dyes, 17th CRSI National Symposium in Chemistry, 06-08 February, 2015, CSIR-NCL, Pune.
  • S. Titus and K.G. Sreejalekshmi, Design and synthesis of coumarinoyl-1,3-thiazole conjugated PAMAM as multifunctional fluorescent dendritic nanoprobes, 17th CRSI National Symposium in Chemistry, 06-08 February, 2015, CSIR-NCL, Pune.
  • R. Rakesh and K.G. Sreejalekshmi, Synthesis, crystal structure and electronic properties of a thienylthiazole hybrid- A combined theoretical and experimental approach, 8th Asian Photochemistry conference (APC-2014), 10-13th November, Rajiv Gandhi Convention Centre, Kovalam, Thiruvananthapuram.
  • S. Titus and K.G. Sreejalekshmi, Supramolecular assemblages in multicomponent molecular crystals of 4-hydrazinothiazoles, RSC Roadshow India, 10th November, 2014, IIT-Madras.
  • S. Titus and K.G. Sreejalekshmi, Synthesis and single crystal X-ray studies on aminothiazole monohydrate, a structural analogue to dasatinib, International Conference on Materials and Characterization Techniques (ICMCT-2014), 10- 12th March, 2014,VIT university, Vellore.
  • S. Titus and K.G. Sreejalekshmi, “Synthesis and solvatochromism of coumarin conjugated PAMAM: in search for a novel imaging probe, National Event on Research Scholar’s Day, held at IIST Thiruvananthapuram, India, December 2013.
  • R. Rakesh, S. Titus and K.G. Sreejalekshmi, “Electronic structures and spectroscopic properties of benzopyranone derivatives : A DFT study, National Event on Research Scholar’s Day, held at IIST Thiruvananthapuram, India, December 2013.
  • S. Titus and K.G. Sreejalekshmi,  “Computational approach towards the development of densely functionalized thiazoles as novel anticancer agents” 4th International conference on stem cells and cancer, Haffkines Institute, Mumbai, India, 19-22nd October , 2013. (BEST POSTER AWARD)
  • S. Titus and K.G. Sreejalekshmi, ‘Recent Advances in Computational Drug Design’ (RACDD-2013) held at IISc Bangalore during September 16-17th, 2013 (BEST POSTER AWARD).
  • A.S. Rama Teja, Sarah Titus, R. Rakesh, K.G. Sreejalekshmi; “Hymecromone functionalized poly(4-vinylpyridine) and its photodeformation” National Seminar on Recent Trends in Materials Science and Technology, held at department of Chemistry, Indian Institute of Space Science  and Technology, Thiruvananthapuram, India 10-12th July 2013.
  • Sarah Titus and K.G. Sreejalekshmi; “Molecular Docking studies on densely functionalized hydrazinothiazoles” National event Research Scholar’s Day 2012, held at Indian Institute of Space Science  and Technology, Thiruvananthapuram, India 19-21st December 2012.
  • K.G. Sreejalekshmi, M. Francis and K.N. Rajasekharan; “Polymer supported synthon for combinatorial heterocycle synthesis” International Conference on ‘Polymers for Advanced Technologies’, held at RRL (CSIR), Thiruvananthapuram, India, 14th December 2004.
  • K.G. Sreejalekshmi, T.F.A.F. Reji, S.K.C. Devi and K. N. Rajasekharan; “Isolation and combinatorial analog synthesis of anticancer marine alkaloids”, “International Conference on “Natural Products, Free Radicals and Radioprotectors in Health” held at Department of Biochemistry, Annamalai University, Annamalainagar, India, 17-19 January 2004.
  • K.G. Sreejalekshmi, S. Anusya, V.P. Menon, S. Sengupta and K.N. Rajasekharan; “Versatile approach to bioactive 2,4-diaminothiazoles  by novel solid phase heterocyclic synthesis”, “Fifth National Symposium in Chemistry”, held at CLRI (CSIR), Chennai, India, 7-9 February 2003.
  • S.K.C. Devi, T.F.A.F. Reji, K.G. Sreejalekshmi and K. N. Rajasekharan; “Anticancer marine alkaloids”, National Conference on “Natural Products in Health” held at Department of Biochemistry, Annamalai University, Annamalainagar, India, 26-27 February 2005.
  • S. Sengupta, S.L. Smitha, N.E. Thomas, T.R. Santosh, S.K.C. Devi, K.G. Sreejalekshmi, and K.N. Rajasekharan;  DAT1: “An antimitotic and cytotoxic agent towards cancer cells and a probe for tubulin-microtubule system”, “Proceedings of the International Conference on Biotechnology and Neuroscience”, Cochin, India, 2004.
  • T. F. A. F. Reji, S.K.Chithralekhadevi, S.L. Manju, K.G. Sreejalekshmi and K. N. Rajasekharan; “New indoloyl-2,4-diaminothiazoles as dendrodoine analogs – synthesis and cytotoxicity”, “Fifth National Symposium in Chemistry”, held at CLRI (CSIR), Chennai, India, 7-9 February 2003.
Workshops Attended
  • Two-day workshop on Computational methods in drug discovery at IIST, Thiruvananthapuram during 25-26th February, 2014.
  • One-week National Workshop on Computational Chemistry (NWCC-2012) at IIST, Thiruvananthapuram during 2012
  • Two – day Joint Academies Lecture Workshop on Analytical Chemistry and Environmental Sciences at Mar Ivanios College, Thiruvananthapuram during 11th and 12th of December 2008
  • Three-day workshop on Computational Chemistry at IIITM-k, Technopark, Thiruvananthapuram during 18-21 March 2009
Invited talk
  • Combinatorial Chemistry – Lecture Series. XXVII Refresher Course in Chemistry, Academic Staff College, University of Kerala, Kariavattom on 04th March, 2015.
  • Dynamic Combinatorial Libraries and Drug Design. UGC sponsored National seminar REACS-2015, All Saints College, Thiruvananthapuram on 09, January, 2015
  • Dendrimers as tunable nanostructures for regenerative medicine and targeted drug delivery. SPSI-KU sponsored two-day National Seminar on Frontiers in Polymers and Advanced Materials organized by Department of Chemistry, University of Kerala, Kariavattom on 05th November, 2014.
  • Combinatorial Chemistry an introduction. KSCSTE sponsored two-day National Seminar on “Green Practices   in Chemistry” organised by Mar Ivanios College, Thiruvananthapuram, during 9- 10, October 2014.
  • Trends in Combinatorial Chemistry and Chemoinformatics (Key note address). UGC sponsored Two Day National Seminar, TKM College of Arts and Science, Kollam, 20th-21st March 2014.
  • Combinatorial Chemistry- Principle and Design Strategies. UGC sponsored Two Day National Seminar on Trends in Combinatorial Chemistry and Chemoinformatics, TKM College of Arts and Science, Kollam, 20th-21st March 2014.
  • Combinatorial Chemistry – Lecture Series. XXVI Refresher Course in Chemistry, ASC, University of Kerala, Kariavattom on 07th March, 2014.
  • Concepts in Supramolecular Chemistry. National Conference on Supramolecular Chemistry and Nanomaterials (SUPRANO 13). MSM College, Kayamkulam on 11th December, 2013.
  • Supramolecular Materials Chemistry: Application in Materials Design. National Conference on Supramolecular Chemistry and Nanomaterials (SUPRANO 13). MSM College, Kayamkulam on 11th December, 2013.
  • Nanomedicine as a promise to the future. Vins Christian Women’s College, Tamilnadu, India on 09th March, 2013.
  • Supramolecular Chemistry: from host-guest chemistry towards molecular machines. Fatima Mata National College, Kollam: Diamond Jubilee and IYC Celebrations held at Department of Chemistry, FMN on 08th December 2011.
  • Dendrimers as engineered materials for prospective bionano devices. Materials Research Society of India, Trivandrum Chapter: Annual Day Celebrations, held at IIST during July 2010
  • Solid phase combinatorial protocols for anticancerous heterocycles and their analogs. Materials Research Society of India, Trivandrum Chapter: Annual Day Celebrations, held at Achutha Menon Centre Auditorium, SCTIMST, Trivandrum on May 15th 2007.